Core Attributes
|
Attribute |
Value |
Source |
|
INCI Name |
Avena Sativa Kernel Oil / Avena Sativa Lipid Extract |
Standard nomenclature |
|
Extraction Source |
Oat grain kernels and bran |
|
|
Primary Lipid Components |
Ceramides, oleic acid, linoleic acid, palmitic acid |
|
|
Ceramide Content |
Phytoceramides (skin-compatible) |
|
|
Essential Fatty Acids |
Omega-6 (linoleic acid), Omega-9 (oleic acid) |
|
|
Bioactive Compounds |
Avenanthramides (anti-inflammatory phenolics) |
|
|
Vitamin E Content |
Tocopherols and tocotrienols (antioxidants) |
|
|
Phenolic Acids |
Ferulic acid, caffeic acid |
|
|
Non-comedogenic Rating |
Non-comedogenic |
|
Clinical Efficacy Attributes
Atopic Dermatitis Studies
|
Parameter |
Result |
Duration |
Source |
|
Eczema severity |
Significant improvement |
2 weeks |
|
|
Itch sensation |
Significant reduction |
2 weeks |
|
|
Topical corticosteroid use |
Significantly reduced requirement |
Study period |
|
|
Scaling and dryness |
More reduced than vehicle (p=0.03, p=0.004) |
21 days |
|
|
Skin hydration |
Significantly higher at 21 days and 1-week post |
21+ days |
|
Barrier Function Studies
|
Parameter |
Result |
Duration |
Source |
|
TEWL (Transepidermal water loss) |
Consistently lower values, improved barrier integrity |
14 days onward |
|
|
Stratum corneum hydration |
Progressive improvement |
4 weeks |
|
|
Plasma IgE levels |
Reduced (nearly 3x lower in treatment group) |
Study period |
|
|
Dermal thickness |
Reduced in oxazolone-induced ACD |
14-21 days |
|
Pediatric Studies (3 months - 12 years)
|
Parameter |
Result |
Duration |
Source |
|
Skin hydration |
Significantly improved |
2 weeks |
|
|
Itching |
Decreased vs baseline |
2 weeks |
|
|
Erythema |
Decreased vs baseline |
2 weeks |
|
|
Tactile roughness |
Decreased vs baseline |
2 weeks |
|
|
Pruritis |
Improved compared to baseline |
2 weeks |
|
|
Lichenification |
Improved compared to baseline |
2 weeks |
|
|
Tolerability |
Well tolerated (only 2 mild, transient events) |
2 weeks |
|
Anti-Inflammatory Efficacy
|
Parameter |
Result |
Source |
|
Inflammatory response reduction |
Up to 30% reduction |
|
|
SLS-induced irritation |
Modulated through anti-inflammatory effects |
|
Mechanism Attributes
Barrier Reinforcement
|
Mechanism |
Action |
Source |
|
Phytoceramide delivery |
Reinforces stratum corneum lipid lamellae |
|
|
Occlusive barrier formation |
Prevents transepidermal water loss |
|
|
Lipid production genes |
Increases expression of lipid synthesis genes |
|
|
Tight junction formation |
Enhances genes encoding tight junction proteins |
|
|
Keratinocyte differentiation |
Increases barrier protein expression (claudin-1, involucrin, zonula occludens-1) |
|
|
Acid mantle support |
Promotes skin pH balance |
|
Moisturization Mechanisms
|
Mechanism |
Action |
Source |
|
Essential fatty acid delivery |
Oleic acid (Omega-9), linoleic acid (Omega-6) provide deep nourishment |
|
|
Lactic acid production stimulation |
Increases NMF (Natural Moisturizing Factor) humectant |
|
|
Moisture retention |
Locks in hydration through occlusive and humectant properties |
|
|
TEWL reduction |
Prevents water evaporation from epidermis |
|
Anti-Inflammatory Mechanisms
|
Mechanism |
Action |
Source |
|
Avenanthramide action |
Inhibits release of inflammatory mediators |
|
|
Inflammatory response reduction |
Up to 30% reduction in inflammatory responses |
|
|
Cytokine modulation |
Reduces pro-inflammatory cytokines |
|
|
IgE reduction |
Decreases plasma IgE (inflammation trigger) |
|
|
Redness and irritation relief |
Visible calming of inflamed skin |
|
Antioxidant Protection
|
Mechanism |
Action |
Source |
|
Vitamin E delivery |
Tocopherols and tocotrienols neutralize free radicals |
|
|
Phenolic acid protection |
Ferulic acid and caffeic acid provide antioxidant defense |
|
|
UV damage mitigation |
Protects against UV-induced oxidative stress |
|
|
Collagen preservation |
Protects existing collagen from degradation |
|
Skin Recovery
|
Mechanism |
Action |
Source |
|
Wound healing acceleration |
Promotes tissue repair |
|
|
Growth-promoting nutrients |
Speeds recovery of compromised skin |
|
|
Post-procedure repair |
Ideal for recovering skin integrity |
|
Sebum Regulation
|
Mechanism |
Action |
Source |
|
Oil production balancing |
Signals adequate moisture, reduces excess sebum |
|
|
Lightweight composition |
Skin-compatible lipids prevent over-stimulation |
|
Application Attributes
|
Application Type |
Concentration |
Purpose |
|
Atopic dermatitis treatments |
1-5% oat lipids |
Barrier repair, inflammation reduction |
|
Sensitive skin formulations |
1-3% oat lipids |
Soothing, calming, irritation relief |
|
Barrier repair creams |
2-5% oat lipids |
TEWL reduction, ceramide delivery |
|
Dry skin moisturizers |
2-4% oat lipids |
Deep nourishment, hydration |
|
Post-procedure care |
1-3% oat lipids |
Recovery acceleration, barrier restoration |
|
Infant/pediatric products |
1-3% oat lipids |
Gentle barrier support, eczema management |
|
Anti-aging treatments |
2-3% oat lipids |
Firmness support, collagen protection |
Dosage Attributes
|
Parameter |
Value |
Source |
|
Topical Concentration |
1-5% oat lipid extract in finished products |
Clinical studies |
|
Colloidal oat equivalent |
1% colloidal oatmeal cream effective |
|
|
Application Frequency |
Twice daily (morning and evening) |
|
|
Minimum Treatment Duration |
2 weeks for eczema symptom improvement |
|
|
Optimal Treatment Duration |
4 weeks for sustained barrier function improvement |
|
|
Results Timeline Week 2 |
Significant eczema severity, itch, hydration improvement |
|
|
Results Timeline Week 3 |
Scaling, dryness, itch relief significant vs vehicle |
|
|
Results Timeline Week 4 |
Sustained hydration, progressive TEWL reduction |
|
|
Immediate Effects |
Soothing relief for irritated/inflamed skin |
|
How Oat Lipids Work in YourHappyLife Formulations
Integration: YourHappyLife incorporates oat lipids as soothing emollients that calm irritation, deeply nourish skin, strengthen the barrier, and leave texture soft, smooth, hydrated, and comforted all day.
Multi-Pathway Action:
-
Barrier Reinforcement: Phytoceramides penetrate stratum corneum → Integrate into lipid lamellae → Strengthen barrier structure → Reduce TEWL
-
Deep Moisturization: Essential fatty acids (oleic, linoleic) → Provide lipid nourishment → Stimulate lactic acid/NMF production → Lock in hydration
-
Anti-Inflammatory: Avenanthramides → Inhibit inflammatory mediators → Reduce cytokines, IgE → Calm redness, itching, irritation (30% reduction)
-
Keratinocyte Support: Increase expression of differentiation proteins (claudin-1, involucrin, ZO-1, filaggrin) → Optimize barrier formation → Improve integrity
-
Antioxidant Defense: Vitamin E, phenolic acids → Neutralize free radicals → Protect collagen, prevent UV damage → Support firmness
-
Sebum Regulation: Lightweight skin-compatible lipids → Signal adequate moisture → Reduce excess oil production → Balance combination skin
Result: Comprehensive barrier restoration, immediate soothing, sustained hydration, reduced inflammation—validated in atopic dermatitis and sensitive skin populations.
Safety Attributes
|
Safety Parameter |
Status |
Source |
|
Clinical Validation |
Extensively studied in controlled trials |
|
|
FDA Recognition |
Colloidal oat: FDA OTC Skin Protectant monograph (2003) |
|
|
All Skin Types |
Suitable including highly sensitive, reactive |
|
|
Pediatric Safety |
Safe for infants 3+ months and children |
|
|
Atopic Dermatitis |
Effective and safe; reduces corticosteroid need |
|
|
Eczema/Psoriasis |
Beneficial adjuvant treatment |
|
|
Adverse Events |
Only 2 mild, transient events (64 pediatric subjects) |
|
|
Oat Allergy |
Rare; topical oat oil generally well-tolerated |
|
|
Gluten Sensitivity |
Oat lipids typically safe (proteins not present in properly extracted oil) |
|
|
Non-comedogenic |
Does not clog pores |
|
|
Pregnancy/Nursing |
Safe (natural botanical lipids) |
General botanical safety |
|
Long-term Use |
Safe for continuous daily application |
|
|
Post-procedure |
Ideal for compromised skin recovery |
|
Product Compatibility Attributes
|
Compatible Ingredient |
Synergy Effect |
|
Ceramides (synthetic) |
Enhanced barrier lipid complex |
|
Hyaluronic acid |
Complementary hydration (humectant + emollient) |
|
Niacinamide |
Barrier support + anti-inflammatory synergy |
|
Colloidal oatmeal |
Comprehensive oat bioactive delivery |
|
Licochalcone |
Anti-inflammatory enhancement |
|
Castor oil |
Emollient synergy |
|
Peptides |
Barrier repair + collagen support |
