Resveratrol

Scientific Name

3,5,4'-trihydroxy-trans-stilbene

Overview

Entity: Resveratrol
Entity Type: Polyphenolic stilbenoid antioxidant
Chemical Class: Stilbene polyphenol
Natural Sources: Red grapes (skin), red wine, peanuts, berries, mulberries, raspberries, tomatoes, strawberries, nuts
Brand Positioning: Powerful antioxidant that neutralizes free radicals, protects against UV damage, brightens dullness, and supports firm, luminous, youthful-looking skin.

Core Attributes

Attribute	Value	Source
INCI Name	Resveratrol
Chemical Name	3,4',5-trihydroxystilbene
CAS Number	501-36-0	Standard database
Molecular Formula	C₁₄H₁₂O₃	Standard database
Molecular Weight	228.25 g/mol	Standard database
Active Form	Trans-resveratrol
Compound Classification	Polyphenol, phytoestrogen, phytoalexin
Bioactive Derivatives	Resveratrol isobutyrate, resveratrol butyrate, resveratryl triglycolate
Most Effective Forms	Isobutyrate and butyrate derivatives

Clinical Efficacy Attributes

12-Week Topical Study

Parameter	Result	Source
Fine lines	Significant improvement
Wrinkles	Significant reduction
Skin elasticity	Significantly improved

45-Day Study (24 volunteers)

Parameter	Responders	Source
Pore size reduction (forehead)	19 of 24 subjects
Pore size reduction (buccal area)	14 of 24 subjects
Pigmentation decrease (forehead)	7 of 24 subjects
Pigmentation decrease (buccal area)	4 of 24 subjects

60-Day Oral Supplementation

Parameter	Result	Source
Skin hydration	Improved
Skin texture	Smoother
Eczema/psoriasis	Condition improved

UV-Irradiated Fibroblast Studies

Biomarker	Effect vs Control	Source
Procollagen 1	Higher content after UV exposure
Matrix metalloproteinase 1	Lower activity
Elastin	Prevented UV-induced decrease

Mechanism Attributes

Gene Induction

Gene/Protein	Effect	Source
Collagen type A1	Increased synthesis
TIMP-1 (Tissue inhibitor of MMPs)	Increased expression
Fibrillin 1	Increased (derivatives only; pure resveratrol neutral)
AMPK	Activated
Autophagocytes	Stimulated production
LC3-II	Increased (autophagy marker)

Gene/Pathway Inhibition

Target	Effect	Source
Survivin	Blocks protein and mRNA
Cyclin-dependent kinase 2, 4, 6	Inhibited
Nuclear factor κB	Blocked
Cyclin D1, D2	Inhibited
Matrix metalloproteinase 1	Blocked (prevents collagen degradation)
Matrix metalloproteinase 9	Decreased through gene interaction
IκB kinase Rα	Inhibited
MAPK	Blocked
MAPKK	Blocked
Leukocyte migration	Reduced (UV-B dependent)
Tyrosinase	Inhibited (reduces discoloration)
Bcl-2 phosphorylation	Inhibited
Protein kinase B and C	Reduced
Hydroperoxidases	Reduced
GM-CSF	Inhibited (wrinkle reduction)

Antioxidant Mechanisms

Mechanism	Action	Source
Free radical scavenging	Neutralizes hydroxyl radicals, nitric oxide, superoxide anions
Dual antioxidant effect	Direct neutralization + boosts endogenous antioxidants
Oxidative stress mitigation	Activates Nrf2 pathway
Lipid peroxidation reduction	Decreases hydroperoxide
Cell protection	Protects against sodium nitroprusside-induced damage
Caspase inhibition	Full blockade of caspase 3 and 9 at 1-30 μmol

Anti-Aging Pathways

Mechanism	Action	Source
Collagen gene activation	Activates estrogen receptor α and β (not γ)
MMP inhibition	Prevents collagen/elastin degradation
SIRT-1 activation	Mimics caloric restriction, improves cellular longevity
AMPK-FOXO3 pathway	Protects keratinocytes from H₂O₂ damage
Autophagy promotion	Eliminates abnormal cells via LC3-II increase

UV Protection Mechanisms

Mechanism	Action	Source
UV-B damage prevention	Protects against photoaging
Inflammatory cytokine reduction	Reduces IL-6 and IL-8 (isobutyrate/butyrate forms)
Skin edema reduction	Decreases UV-induced swelling
Erythema reduction	Decreases UV-induced redness
Wrinkle formation prevention	Reduces UV-induced wrinkle number and length

Melanogenesis Inhibition

Mechanism	Action	Source
Tyrosinase inhibition	Blocks melanin synthesis enzyme
MITF blockade	Inhibits microphthalmia-associated transcription factor
Tyrosinase mRNA reduction	Decreases enzyme expression
DOPA chrome tautomerase inhibition	Blocks melanin production pathway
Melanin concentration decrease	3-10 μmol dose reduces melanin in melanoma cells
Melanosomal degradation	Activates autophagy, lysosomal, proteasomal pathways

Application Attributes

Application Type	Concentration	Purpose
Anti-aging serums	0.5-2%	Wrinkles, fine lines, firmness
Photoprotection products	1-2%	UV damage prevention
Brightening treatments	1% (resveratryl triglycolate 3-10 μmol)	Hyperpigmentation, melanoma protection
Antioxidant formulations	0.5-1%	Free radical defense
Scar/wound healing	1-2% topical	Tissue regeneration
Anti-inflammatory products	0.5-1%	Redness, irritation, dermatitis
Oral supplements	100-500 mg daily	Systemic skin health

Dosage Attributes

Parameter	Value	Source
Topical Concentration	0.5-2% in finished products	General cosmetic use
Melanogenesis Inhibition	3-10 μmol resveratryl triglycolate
UV Protection	25-50 μmol (cell culture studies)
Oral Supplementation	100-500 mg daily
Application Frequency	1-2 times daily	Standard skincare protocol
Topical Results Timeline	12 weeks for significant wrinkle/elasticity improvement
Oral Results Timeline	60 days for hydration/texture improvement

How Resveratrol Works in YourHappyLife Formulations

Integration: YourHappyLife incorporates resveratrol as powerful antioxidant that neutralizes free radicals, protects against UV damage, brightens dullness, and supports firm, luminous, youthful-looking skin.

Multi-Pathway Action:

Antioxidant: Scavenges hydroxyl radicals, nitric oxide, superoxide anions → Prevents oxidative cellular damage
Collagen Protection: Inhibits MMP-1 and MMP-9 → Prevents collagen/elastin breakdown
Collagen Synthesis: Activates estrogen receptors α/β → Increases type A1 collagen gene expression
UV Defense: Blocks MAPK/MAPKK, reduces leukocyte migration → Prevents photoaging
Anti-Inflammatory: Reduces IL-6, IL-8 (isobutyrate/butyrate forms) → Calms skin, reduces redness
Brightening: Inhibits tyrosinase, MITF, melanin synthesis → Fades hyperpigmentation
Cellular Longevity: Activates SIRT-1, AMPK-FOXO3 → Protects cells, promotes autophagy

Derivative Comparison

Form	IL-6/IL-8 Reduction	Collagen A1 Increase	TIMP-1 Increase	Fibrillin 1 Effect	MMP-9 Decrease
Resveratrol isobutyrate	Strongest	High	High	Increases	High
Resveratrol butyrate	Strongest	High	High	Increases	High
Pure resveratrol	Moderate	Moderate	Moderate	No change	Moderate

Source:

Safety Attributes

Safety Parameter	Status	Source
Clinical Validation	Extensively studied in humans
All Skin Types	Suitable
Sensitive Skin	Well-tolerated
Pregnancy Safety	Consult healthcare provider	General phytoestrogen caution
Oral Safety	GRAS at 100-500 mg/day
Side Effects (topical)	Minimal; rare mild irritation
Side Effects (oral)	None reported at standard doses
Dermatological Conditions	Benefits eczema, psoriasis, dermatitis
Photosensitivity	None (actually provides photoprotection)
Long-term Use	Safe for continuous application

Formulation Challenges & Solutions

Challenge	Issue	Solution
Low aqueous solubility	Poor water dispersibility	Use derivatives or nanocarriers
Light sensitivity	Degrades under UV exposure	Opaque/amber packaging
Oxidation susceptibility	Loses potency with air exposure	Airless pump, antioxidant stabilizers
Bioavailability	Limited skin penetration	Nanoencapsulation, liposomes, derivatives

Product Compatibility Attributes

Compatible Ingredient	Synergy Effect
Vitamin C	Enhanced antioxidant protection
Vitamin E	Antioxidant network amplification
Ferulic acid	Photoprotection synergy
Niacinamide	Barrier + anti-inflammatory synergy
Peptides	Multi-pathway collagen stimulation
Hyaluronic acid	Hydration + antioxidant combination
Bakuchiol	Complementary retinol-like effects

Resveratrol

Scientific Name

3,5,4'-trihydroxy-trans-stilbene

Previous Ingredient

Next Ingredient